From drug-discovery or diagnostic assays to basic research, monoclonal antibodies (mAbs) are common and essential reagents for a wide variety of clinical and research applications. Unfortunately, generating a high-quality antibody is not nearly as straightforward as their popularity might suggest, and reproducibility has been a growing concern ...

Immunology: Rabbit antibodies show potential for diagnosis and treatment

Highly specialized antibodies derived from rabbits could transform our ability to detect and treat diseases such as cancer and HIV. Christoph Rader and co-workers at The Scripps Research Institute in Florida, USA, reviewed the use of rabbit antibodies in research, diagnostics and therapy. Rabbits are commonly used as models in immunology because of their highly sensitive immune system, which generates large numbers of antibodies in response to multiple antigens. Rabbit polyclonal antibodies, antibodies that target different 'epitopes' (or sites) on an antigen molecule, are used to prevent and treat transplant rejection. Rader's team highlights the outstanding performance in pre-clinical studies of novel rabbit monoclonal antibodies (mAbs), highly specialised antibodies that target single epitopes. Among many potential applications, rabbit mAbs can detect and destroy cancer cells, and may aid in developing vaccines for diseases like HIV.

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