Description:

1. B18R is a virally-encoded protein that acts as a decoy receptor for Type I Interferons (IFNα, IFNβ, IFNε, κ, τ, Δ, ζ, ώ, v), thereby allowing viral replication by inhibiting IFNα1 and IFNα2 responses. B18R was recently identified to enable increased cell viability during RNA transfection designed to convert human somatic donor cells into iPSCs via direct delivery of synthetic mRNAs for OCT4, SOX2, KLF4 and MYC (OSKM) and Lin28 with the aim to enable highly efficient reprogramming of somatic cells to pluripotency. This allows for re-directed differentiation toward a desired lineage while removing the risk of genomic integration and insertional mutagenesis inherent to DNA-bases methodologies and eliminates the need for virus-based approaches. iPSCs represent a widely available, non-controversial and practically infinite source of pluripotent cells.

Source:

1. 2 mg/ml in 25 mM Tris-HCl, pH8.0, 50 mM NaCl, 1 mM TCEP, 50% glycerol

Protein sequence:

1. B18R-Fc (human IgG1 Fc)

Technique FAQ:

1. Contact:Stemgent Inc.for purchasing.