PTM Antibody development service
Exonbio leverages SPIN® technology to develop PTM Antibody that are highly specific to post-translational modifications such as phosphorylation, methylation, glycosylation, ubiquitination, acetylation, and more.
Benefits
Powerful counter selection
Counter selection to significantly increase efficiency. >90% of clones isolated are post-translation modification specific.
High Specificity
Counter selection helps in developing antibodies highly specific to the modification
Large variety of modification
Phosphorylation, methylation, glycosylation ubiquitation, acetylation and more.
High affinity
Antibodies generated against PTM range around single digit nanomolar KD
Benefits
Powerful counter selection
· Counter selection to significantly increase the efficiency
· >90% of clones isolated are post translation modification specific
High Specificity
Counter selection helps in developing antibodies highly specific to the modification
Large variety of modification
Phosphorylation, methylation, glycosylation ubiquitation, acetylation and more.
High affinity
Antibodies generated against PTM range around single digit nanomolar KD
PTM antibody development with SPIN® tech
PTM antibody is critical in the study of signal transduction. Post-translational modification (PTM) is one of the mechanisms that enables the massive functional extension from the genome to the proteome, allowing each translated protein to act in specific ways, at specific times, and in specific cells and tissues. Counter selection using non-modified peptide makes it more effective to isolate antibodies against the modification site.
SPIN® technology allows to generate large number of PTM specific antibodies.
Service Highlights
Proven track record of 100% success rate
Identify antibody pairs by epitope binning
Affinity ranking using Biacore kinetic analysis