Recombinant SARS-CoV-2 Nucleocapsid Protein (R385K)

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Description

Protein Name: 2019-nCoV Nucleocapsid Protein (R385K)

Protein Purification: Full-length SARS-CoV-2 Nucleocapsid protein, Met1-Ala419, with point mutation R385K and a C-terminal His-tag. R385K mutation is the same NP mutation which was identified on the SARS-CoV-2 variant (B.1.617) which emerged in India.

Alternative Name: Protein N, NC

Protein Construction: N protein with C-terminal His-tag

Endotoxin: <0.1 EU/ug

Expression Host: E. coli

Protein type: Recombinant

Purification tag: His-tag

Formulation: PBS

Regulation restrictions: For research use only

Shipping: Recombinant proteins are provided as frozen liquid and will be shipped out with dry ice

Stability and storage: The protein is stable in a liquid state at -70℃ for 12 months. Avoid repeated freeze-thaw cycles

Background Information

The nucleocapsid (N) protein is the structural component of the viral structure and it primarily functions to bind coronavirus RNA genome. The N protein is the most abundant protein in coronavirus. It is normally very conserved and is highly immunogenic phosphoprotein. It is also involved in CoV replication cycle and the host cellular response to viral infection. The localization of N to the endoplasmic reticulum (ER)-Golgi region has proposed a function for it in assembly and budding. This protein can be used as a marker for diagnostic tests for Covid-19.

References:
1. https://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1182-0