Human ACE2 Protein
$350.00 – $1,500.00
|Recombinant Human ACE2 Protein
|Angiotensin-converting enzyme 2, hACE2
|95% or above
|Human ACE2 protein containing Gln18-Asp615 (Accession # Q9BYF1-1) C-terminal fusion with rabbit IgG Fc
|<0.1 EU per ug of protein as determined by LAL method
|Homo sapiens (Human)
|C-terminal rabbit IgG Fc. Protein A column purified
|Predicted molecular weight 194 kD
|For research use only
|Recombinant proteins are provided as frozen liquid and will be shipped out with dry ice.
|Stability and storage
|The protein is stable in a liquid state at -70℃ for 12 months. Avoid repeated freeze-thaw cycles.
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.