|Protein Name||Recombinant Human ACE2 Protein|
|Alternative Name||Angiotensin-converting enzyme 2, hACE2|
|Purity||95% or above|
|Protein Construction||Human ACE2 protein containing Gln18-Asp615 (Accession # Q9BYF1-1) C-terminal fusion with rabbit IgG Fc|
|Endotoxin||<0.1 EU per ug of protein as determined by LAL method|
|Origin Species||Homo sapiens (Human)|
|Purification tag||C-terminal rabbit IgG Fc. Protein A column purified|
|Molecule Mass||Predicted molecular weight 194 kD|
|Regulation restrictions||For research use only|
|Shipping||Recombinant proteins are provided as frozen liquid and will be shipped out with dry ice.|
|Stability and storage||The protein is stable in a liquid state at -70℃ for 12 months. Avoid repeated freeze-thaw cycles.|
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible.
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