M. Tuberculosis Rabbit Monoclonal Antibody – LAM, 2H4
$350.00 – $1,500.00
|Product Name||M. Tuberculosis Rabbit Monoclonal Antibody - LAM, 2H4|
|Preparation||Recombinant monoclonal antibody expressed in HEK293F cells and purified by protein A affinity chromatography.|
|Applications||ELISA, Indirect Immunofluorescence Assay, Lateral Flow|
|Reactivity||M. tuberculosis – LAM|
|Isotype||rabbit IgG, kappa|
|Purification||Protein A affinity chromatography|
|Storage conditions||For long term storage, the antibody should be stored at -20℃ and is stable for 12 months from the date of receipt. Avoid repeated freeze-thaw cycles. For short term storage, keep at 4oC for a week should be fine.|
|Application Dilution||1:1,000-1:100,000 (platform dependent, customers must test the optimal concentration on their own platform)|
Tuberculosis (TB) is still a severe public health problem; the current diagnostic tests have limitations that delay treatment onset. Lipoarabinomannan (LAM) is a glycolipid that is a component of the cell wall of the bacillus Mycobacterium tuberculosis, the etiologic agent of TB. This glycolipid is excreted as a soluble form in urine. The World Health Organization has established that the design of new TB diagnostic methods is one of the priorities within the EndTB Strategy. LAM has been suggested as a biomarker to develop diagnostic tests based on its identification in urine, and it is one of the most prominent candidates to develop point-of-care diagnostic test because urine samples can be easily collected. Moreover, LAM can regulate the immune response in the host and can be found in the serum of TB patients, where it probably affects a wide variety of host cell populations, consequently influencing the quality of both innate and adaptive immune responses during TB infection.
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