Kappa Free Light Chain (FLC) Rabbit Monoclonal Antibody, 4C2

EX-4C2FLC-KEX-4C2FLC-K

$350.00$1,500.00

Product Name Kappa Free Light Chain (FLC) Rabbit Monoclonal Antibody, 4C2
Catalog Number EX-4C2FLC-KEX-4C2FLC-K
Immunogen Purified Human Free Light Chain (FLC) - Kappa
Host Rabbit
Preparation Recombinant monoclonal antibody expressed in HEK293F cells and purified by protein A affinity chromatography.
Isotype rabbit IgG, kappa
Conjugation Unconjugated
Clonality Monoclonal
Concentration 1mg/ml
Purification Protein A affinity chromatography
Storage buffer PBS
Storage conditions For long term storage, the antibody should be stored at -20℃ and is stable for 12 months from the date of receipt. Avoid repeated freeze-thaw cycles. For short term storage, keep at 4oC for a week should be fine.
Application Dilution 1:1,000-1:100,000 (platform dependent, customers must test the optimal concentration on their own platform)

Additional information

Size

100µg, 1mg

Background information

Free light chains (FLCs) are small protein components produced by plasma cells, which are a type of white blood cell involved in the immune system. Normally, these light chains are part of antibodies (immunoglobulins), but they can also circulate freely in the blood when not bound to heavy chains. FLCs are classified into two types: kappa and lambda, based on their structure.
In healthy individuals, FLCs are present in the blood at low levels, but certain diseases, particularly those involving abnormal plasma cell proliferation such as multiple myeloma, AL amyloidosis, and other B-cell disorders, can lead to elevated levels of FLCs. The balance between kappa and lambda FLCs can also be disrupted in these conditions, providing valuable diagnostic information.

Measurement of FLCs in the blood is an important diagnostic tool in hematology and oncology. It helps in the detection, diagnosis, and monitoring of plasma cell disorders. Monoclonal antibodies that specifically target kappa and lambda free light chains are commonly used in immunoassays to measure FLC concentrations accurately. These assays are critical for early diagnosis, treatment planning, and monitoring disease progression or remission.

Datasheet

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Validation data

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