Influenza B NP Monoclonal Antibody, 300-1E3

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Background information

Flu A virus is the most common flu virus infecting humans, animals, and birds. It is divided into subtypes, based on the nature of their surface glycoproteins, HA and NA. There are 18 different HAs and 11 NAs that are distinguishable serologically (antibodies to one virus subtype do not react with another). In comparison, Flu B infection mostly occurs in humans and is divided into lineages and strains. Currently circulating influenza B viruses belong to one of the two lineages: B/Victoria and B/Yamagata. This virus is responsible for significant morbidity which is why the seasonal trivalent influenza vaccine contains Flu B as an integral component. Unlike Flu A or B, Influenza C viruses only cause a mild respiratory illness in humans and secondary complications are rare. Flu C is structurally different from Flu A and B viruses and contains a glycoprotein called HEF (hemagglutinin-esterase-fusion).

Influenza viruses are mostly spread by aerosolization made when an infected person coughs or sneezes. Complications usually arise from bacterial infections of the lower respiratory tract and signs of a secondary respiratory infection often appear just as the infected person seems to be recovering. The elderly and the chronically ill are at greater risk for secondary infection and other complications. Children can also experience a rare, but serious complication called Reye’s syndrome.

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